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光学医療診療部 肝疾患センター
研究・業績
研究論文(英文)
●英語論文
Nagumo K, Tanaka M, Chuang V, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T.
Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases.
PLOS ONE 9: e85216, 2014
Isono K, Jono H, Ohya Y, Shiraki N, Yamazoe T, Sugasaki A, Era T, Fusaki N, Tasaki M, Ueda M, Shinriki S, Inomata Y, Kume S, Ando Y.
Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells.
Stem Cell Res. 2014 Jan 27;12 (2):574-583
Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S.
VMAT2 identified as a regulator of late-stage β-cell differentiation.
Nat Chem Biol. 2014 Feb;10(2):141-8
Yamazoe T, Shiraki N, Kume S,
Hepatic differentiation from murine and human iPS cells using nanofiber scaffolds.
Methods Mol Biol. 2014 Nov; (Epub ahead of print)
Miyamoto H, Ikematsu H, Fujii S, Osera S, Odagaki T, Oono Y, Yano T, Ochiai A, Sasaki Y, Kaneko K.
Clinicopathological differences of laterally spreading tumors arising in the colon and rectum.
Int J Colorectal Dis. 29(9): 1069-1075, 2014
Nagaoka K, Hino S, Sakamoto A, Anan K, Takase R, Umehara T, Yokoyama S, Sasaki Y and Nakao M.
Lysine-specific demethylase LSD2 suppresses lipid influx and metabolism in hepatic cells.
Molecular Cellular Biology in press
Nagumo K, Tanaka M, Chuang V, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T.
Cys34-cysteinylated human serum albmin is a sensitive plasma marker in oxidative stress-related chronic disease.
PLOS ONE in press
Miyamoto H, Oono Y, KL F, Ikematsu H, Fujii S, Kojima T, Yano T, Ochiai A, Sasaki Y, Kaneko K.
Morphological change of a laterally spreading rectal tumor over a short period.
BMC Gastroenterology 19;13:129, 2013
Nishimura C, Naoe H, Hashigo S, Tsutsumi H, Ishii S, Konoe T, Watanabe T, Shono T, Sakurai K, Takahashi K, Ikuta Y, Chikamoto A, Tanaka M, Iyama K, Baba H, Katabuchi H, Sasaki Y.
Pancreatic metastasis from mixed adenoneuroendocrine carcinoma of the uterine cervix: a case report.
Case Rep Oncol 6: 256-262, 2013
Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S.
VMAT2 identified as a regulator of late-stage β-cell differentiation.
Nat Chem Biol Dec 15 doi:10.1038/nchembio.1410, 2013
Yamazoe T, Shiraki N, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Sasaki Y, Kume K, Kume S.
A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells.
J Cell Sci 1: 126, 5391-5399, 2013
Nonaka K, Ban S, Aikawa M, Yamasaki A, Okuda A, Kounoe T, Naoe H, Sakurai K, Miyazawa M, Kita H, Sasaki Y.
Electrocautery therapy combined with oral steroid administration for refractory corrosive esophageal stenosis prevents restenosis.
Esophagus 10: 230-234, 2013
Umeda K, Suzuki K, Yamazoe T, Shiraki N, Higuchi Y, Tokieda K, Kume K, Mitani K, Kume S.
Alubumin gene targeting in human embryonic stem cells and induced pluripotent stem cells with helper-dependent adenoviral vector to monitor hepatic differentiation.
Stem Cell Res 10: 19-194, 2013
Matsuhisa T, Arakawa T, Watanabe T, Tokutomi T, Sakurai K, Okamura S, Chono S, Kamada T, Sugiyama A, Fujimura Y, Matsuzawa K, Ito M, Yasuda M, Ota H, Haruma K.
Relation between bile acid reflux into stomach and the risk of atrophic gastritis and intestinal metaplasia: a multicenter study of 2283 cases.
Dig Endosc 25: 519-525, 2013
Nonaka K, Watanabe M, Yuruki H, Okuda A, Sakuari K, Iyama K, Sasaki Y.
Narrow band imaging of adenocarcinoma arising from ectopic gastric mucosa in the upper esophagus.
Endoscopy 45, 2013
Hino S, Nagaoka K, Nakao M.
Metabolism-epigenome crosstalk in physiology and diseases.
J Hum Genet 58: 410-415, 2013
Naoe H, Chiyoda T, Ishizawa J, Masuda K, Saya H, Kuninaka S.
The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells.
Biochem Biophys Res Commun 430:757-762, 2013
Kawaguchi T, Komori A, Seike M, Fujiyama S, Watanabe H, Tanaka M, Sakisaka S, Nakamuta M, Sasaki Y, Oketani M, Hattori T, Katsura K, Sata M.
Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, Phase II study.
J Gastroenterol 47, 1342-1351, 2012
Nonaka K, Ishikawa K, Arai S, Nakao M, Shimizu M, Sakurai T, Nagata K, Nishimura M, Togawa O, Ochiai Y, Sasaki Y, Kita H.
A case of gastric musosa-associated lymphoid tissue lymphoma in which magnified endoscopy with narrow band imaging was useful in the diagnosis.
World J Gastrointest Endosc 16: 151-156, 2012
Hirosue A, Ishihara K, Tokunaga K, Watanabe T Saitoh N, Nakamoto M, Chandra T, Narita M, Shinohara M and Nakao M.
Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells.
Aging Cell 11: 553-556, 2012
Watanabe T, Ishihara K, Hirosue A, Watanabe S, Hino S, Ojima H, Kanai Y, Sasaki Y, and Nakao M.
Higher-order chromatin regulation and differential gene expression in human Tumor necrosis factor / Lymphotoxin locus in hepatocellular carcinoma cells.
Mol Cell Biol 32: 1529-1541, 2012
Naoe H, Iwasaki H, Kawasaki T, Ozaki T, Tsutsumi H, Okuda A, Konoe T, Nonaka K, Kaku E, Shono T, Yokomine k, Sakurai K, Iyama K, Hirota M, Sasaki Y.
Primary hepatic gastrinoma as an unusual manifestation of Zollinger-Ellison syndrome.
Case Reports in Gastroenterology 6:590-595, 2012
Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki D, Ishihara Y, Saya H, Kuninaka S.
LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.
J Cell Biol 28; 197, 625-641, 2012
Hino S, Sakamoto A, Nagaoka K, Anan K, Wang Y, Mimasu S, Umehara T, Yokoyama S, Kosai K, Nakao M.
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.
Nat Commun 27: 758, 1-12, 2012
Sakurai K, Nagahara A, Inoue K, Akiyama J, Mabe K, Suzuki J, Habu Y, Araki A, Suzuki T, Satoh K, Nagami H, Harada R, Tano N, Kusaka M, Fujioka Y, Fujimura T, Shigeto N, Oumi T, Miwa J, Miwa H, Fujimoto K, Kinoshita Y, Haruma K.
Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS).
BMC Gastroenterol 1; 12:42, 2012
Shono T, Nonaka K, Ochiai Y, Nakao M, Togawa O, Nishimura M, Ishikawa K, Arai S, Sakurai K, Sasaki Y and Kita H.
Endoscopic diagnosis and treatment of superficial colorectal neoplasm.
Curr Res Cancer 6: 27-41, 2012
Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H and Kuninaka S.
The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.
Mol Cell Biol(in press)
Dessouki O, Kamiya Y, Nagahama H, Tanaka M, Suzu S, Sasaki Y and Okada S.
Chronic hepatitis C viral infection reduced NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment.
Biochem Biophys Res Commun 393: 331-337, 2010
Nonaka K, Ishikawa K, Arai S, Shimizu M, Sakurai T, Nishimura M, Nakao M, Sasaki Y and Kita H.
Magnifying endoscopic observation of mantle cell lymphoma in the stomach using the narrow-band imaging system
Endoscopy 42: E94-95, 2010
Nonaka K, Arai S, Ishikawa K, Nakao M, Nakai Y, Togawa O, Nagata K, Shimizu M, Sasaki Y and Kita H.
Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms.
World J Gastrointest Endosc 2: 69-74, 2010
Ikeda M, Maeda S, Ashihara H, Nagahama H, Tanaka M and Sasaki Y.
Transcatheter arterial infusion chemotherapy with cisplatin-lipiodol suspension in patients with hepatocellular carcinoma.
J Gastroenterol 45: 60-67, 2010
Yokomine K, Senju S, Nakatsura T, Irie A, Hayashida Y, Ikuta Y, Harao M, Imai K, Baba H, Iwase H, Nomori H, Takahashi K, Daigo Y, Tsunoda T, Nakamura Y, Sasaki Y and Nishimura Y.
The Forkhead Box M1 transcriptional factor as a possible immunotherapeutic tumor-associated antigen.
Int J Cancer 126: 2153-2163, 2009
Yokoo, K., Hamada, A., Tazoe, K., Sasaki, Y. and Saito, H.
Effects of oral administered S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer.
Ther. Drug. Monit 31: 400-403, 2009
Ikuta, Y.,* Hayashida, Y.*, Hirata, Irie, A., Senju, S., Nakatsura, T., Monji, M., Sasaki, Y., Baba, H. and Nishimura, Y. (*These two authors contributed equally.)
Identification of the H2-Kd-restricted CTL epitopes of a tumor-associated antigen, SPARC, which can stimulate antitumor immunity without causing autoimmune disease in mice.
Cancer Sci 100: 132-137, 2009
Iwashita, H., Fujii, S., Kawamura, Y., Okamoto, T., Sawa, T., Masaki, T., Nishizono, A., Higashi, S., Kitamura, T., Tamura, F., Sasaki, Y. and Akaike, T.
Identification of the major antigenic protein of helicobacter cinaedi and the immunogenicity during infections in humans.
Clinical and Vaccine Immunology 15: 513-521, 2008
Kuninaka S, Iida S, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S, Saya H.
Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.
Oncogene 26: 2395-2406, 2007
Yokomine, K., Nakatsura, T., Senju, S., NAkagata, N., Minohara, M., Kira , J., Motomura, Y., Kubo, T., Sasaki, Y. and Nishimura, Y.
Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in ApcMin/+ mice.
Cancer Sci 98: 1930-35, 2007
Sasaki, Y.
Does oxidative stress participate in the development of hepatocellular carcinoma?
J Gastroenterol 41: 1135-48, 2006
Goto, H., Oda, Y., Murakami, Y., Tanaka, T., Hasuda, K., Goto, S., Sasaki, Y. Sakisaka, S. and Hattori, M.
Proportion of de novo cancers among colorectal cancers in Japan.
Gastroenterology 131: 40-46, 2006
Yokomine, K., Nakatsura, T., Monohara, M., Kira, J., Kubo, T., Sasaki, Y. and Nishimura, Y.
Immunization with heat shock protein 105-pulsed dendritic cells leads to tumor rejection in mice.
Biochem. Biophys. Res. Commun 343: 269-278, 2006
Hamada, A., Aoki, A., Terazaki, H., Ito, K., Yokoo, K., Sasaki, Y. and Saito, H.
Pharmacokinetic changes of irinotecan by interstitial alkalinization in an advanced colorectal cancer patient.
Ther. Drug. Monit 27: 536-538, 2005
Nakanishi, F., Ohkawa, K., Ishida, H., Housui, A., Sato, A., Hiramatsu, N., Ueda, K., Takehara, T., Kasahara, A., Sasaki, Y., Hori, M., and Hayashi, N.
Alteration in gene expression profile by full length hepatitis B virus genome.
Intervirology 48: 77-83, 2005
Yoshida K, Nakayama K, Kase S, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ohno S, Nishi S, Nakayama KI.
Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body.
Anat Embryol 208: 145-150, 2004
Yoshida K, Kase S, Nakayama K, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ohno S, Nakayama KI.
Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment.
GraefesArch Clin Exp Ophthalmol 242: 437-441, 2004
Nakayama K*, Nagahama H*, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI. (*These authors contributed equally to this work.)
Skp2-Mediated Degradation of p27 Regulates Progression into Mitosis.
Dev Cell 6: 661-672, 2004
Yoshida K, Kase S, Nakayama K, Nagahama H, Harada T, Ikeda H, Harada C, Imaki J, Ohgami K, Shiratori K, Ilieva IB, Ohno S, Nishi S, Nakayama KI.
Involvement of p27(KIP1) in the Proliferation of the Developing Corneal Endothelium.
Invest Ophthalmol Vis Sci 45: 2163-2167, 2004
Toyama, T., Sasaki, Y., Horimoto, M., Iyoda, K., Yakushijin, T., Ohkawa, K., Takehara, T., Kasahara, A., Araki, T., Hori, M., and Hayashi, N.
Ninjurin increases p21 expression and induces cellular senescence in human hepatoma cells.
J. Hepatol 41: 637-643, 2004.
Uchida, M., Hamada, A., Yamasaki, M., Fujiyama, S., Sasaki, Y., and Saito, H.
Assessment of adverse reactions and pharmacokinetics of ribavirin in combination with interferon α-2b in patients with chronic hepatitis C.
Drug Metabol. Pharmacokin 19: 438-443, 2004.
Imai, Y., Kasahara, A., Tanaka, H., Okanoue, T., Hiramatsu, N., Tsubouchi, H., Yoshioka, K., Kawata, S., Tanaka, E., Hino, K., Hayashi, K., Tamura, S., Itoh, Y., Sasaki, Y., Kiyosawa, K., Kakumu, S., Okita, K., and Hayashi, N.
Interferon therapy for aged patients with chronic hepatitis C: improved survival in patients exhibiting a biochemical response.
J. Gastroenterol 39: 1069-1077, 2004
Ando, Y., Terazaki, H., Nakamura, M., Ando, E., Haraoka, K., Yamashita, T., Ueda, M., Okabe, H., Sasaki, Y., Tanihara, H., Uchino, M., and Inomata, Y.
A different amyloid formation mechanism: de novo oculoeptomeningeal amyloid deposits after liver transplantation.
Transplantation 77: 345-349, 2004.
Ando, Y., Haraoka, K., Terazaki, H., Tanoue, Y., Ishikawa, K., Katsuragi, S., Nakamura, M., Sun, X., Nakagawa, K., Sasamoto, K., Takesako, K., Ishizaki, T., Sasaki, Y., and Doh-ura, K.
A novel tool for detecting amyloid deposits in systemic amyloidosis in vitro and in vivo.
Lab. Invest 83: 1751-1759, 2003.
Yasumaru, M., Tsuji, S., Tsujii, M., Irie T., Komori, M., Kimura, A., Nishida T., Kakiuchi, Y, Kawai, N., Murata H., Horimoto M., Sasaki, Y., Hayashi, N., Kawano, S., and Hori, M.:
Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway.
Cancer Res 63: 6726-34, 2003.
Miyagi, T., Takehara, T., Tatsumi, T., Kanto, T., Suzuki, T., Jinushi, M., Sugimoto, K., Sasaki, Y. Hori, M. and Hayashi N.
CD1d-mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells to eliminate experimentally disseminated hepatoma cells in murine liver.
Int. J. Cancer 106: 81-89, 2003.
Housui, A., Ohkawa, K., Ishida, H., Sato, A., Nakanishi, F., Ueda, K., Takahara, T., kasahara, A., Sasaki, Y., Hori, M. and Hayashi, N.
Hepatitis C virus core protein differently regulates the JAK-STAT signaling pathway under interleukin-6 and interferon-gamma stimuli.
J. Biol. Chem 278: 28562-28571, 2003.
Iyoda, K., Sasaki, Y., Horimoto, M., Toyama, T., Yakushijin, T., Sakakibara, M., Takehara, T., Fujimoto, J., Hori, M., Wands, JR. and Hayashi, N.
Involvement of the p38 mitogen-activated protein kinase cascade in human hepatocellular carcinoma.
Cancer 97: 3017-3026, 2003
Hayashi, N., Kanto, T., Housui, A., Sugimoto, K., Ohkawa, K., Takehara, T.and Sasaki, Y.
Molecular pathogenesis of viral hepatitis.
Inter. Med 42: 290-291, 2003
Okuda, Y., Takahashi, I., Kim, J.K., Ohta, N., Iwatani, Iijima, H., Kai, Y., Tamagawa, H., Hiroi, T., Kweon, M.N., Kawano, S., Takeda, K., Akira, S., Sasaki, Y., Hori, M. and Kiyono, H.
Development of colitis in signal transducers and activators of transcription 6-deficient T cell recedptor α-deficient mice; A potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ ββT cells.
Am. J. Pathology 162: 263-271, 2003
Ohkawa, K., Ishida, H., Nakanishi, F., Housui, A., Sato, A., Ueda, K., Takehara, T., Kasahara, A., Sasaki, Y., Hori, M and Hayashi, N.
Changes in gene expression profile by HCV core protein in cultures liver cells: analysis by DNA array assay.
Hepatol. Res 25: 396-408, 2003
Jinushi, M., Takehara, T., Tatsumi, T., Kanto, T., Groh, V., Spies, T., Kimura, R., Miyagi, T., Mochizuki, K., Sasaki, Y. and Hayashi N.
Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid.
Int. J. Cancer 104: 354-361, 2003
Suzuki, T., Takehara, T., Ohkawa, K., Ishida, H., Jinushi, M., Miyagi, T., Sasaki, Y. and Hayashi, N.
Intravenous injection of naked plasmid DNA encoding hepatitis B virus (HBV) produces HBV and induces humoral immune response in mice.
Biochem. Biophys. Res. Commun 300: 784-788, 2003
Miyagi, T., Tatsumi, T., Takehara, T., Kanto, T., Kuzushita, N., Sugimoto, K., Jinushi, M., Kasahara, A., Sasaki, Y. Hori, M. and Hayashi, N.
Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells.
J. Gastroenterol. Hepatol 18: 32-40, 2003
Jinushi, M., Takehara, T., Kanto, T., Tatsumi, T., Groh, V., Spies, T., Miyagi, T., Suzuki, T., Sasaki, Y. and Hayashi N.
Critical role of MICA/B expression on interferon α-stimutaled dendritic cells in NK cell activation: Impairment in chronic hepatitis C virus infection.
J. Immunol 170: 1249-1256, 2003