@charset "utf-8";
/* 研究者の方へページ専用スタイル */

.content_title {
    font-size: 1.5rem;
    font-weight: 700;
    color: #333;
    margin-bottom: 1.25rem;
    padding-bottom: 0.625rem;
    position: relative;
}

.content_title::after {
    content: "";
    position: absolute;
    bottom: 0;
    left: 0;
    width: 100%;
    height: 0.3125rem;
    border-radius: 0.25rem;
    background: linear-gradient(to right, #fac657, #ffd89e);
}

.content_sub_title {
    font-size: 1.25rem;
    font-weight: 500;
    color: #005b7f;
    margin: 0 0.5rem 0.9375rem 0.5rem;
    padding-top: 1.875rem;
    border-top: 1px solid #e0e0e0;
}

.content_sub_title.first {
    margin-top: 0;
    padding-top: 0;
    border-top: none;
}

.content_subtitle:first-child {
    margin-top: 0;
    padding-top: 0;
    border-top: none;
}

/* セクションタイトル */
.section_title {
    font-size: 1.5rem;
    font-weight: 500;
    color: #005b7f;
    margin: 2.5rem 0 1.25rem;
    padding-left: 0.9375rem;
    border-left: 0.3125rem solid #00a0c1;
    line-height: 1.4;
}

/* 研究者向け特有のスタイル */
.researcher_highlight {
    background-color: #f0f8ff;
    border-left: 0.25rem solid #005b7f;
    padding: 0.9375rem;
    margin: 1.25rem 0;
}

.researcher_highlight h3 {
    color: #005b7f;
    font-size: 1.1rem;
    margin-top: 0;
    margin-bottom: 0.625rem;
}

.content_subheading {
    font-size: 1.1rem;
    font-weight: 600;
    color: var(--secondary-color);
    margin: 1.25rem 0 0.75rem;
    position: relative;
    padding-left: 0.9375rem;
    border-left: 4px solid var(--primary-color);
}


.table_container {
    margin-bottom: 3.5rem;
}


/* テーブルスタイル - 薄い緑色 */
.pharmaceutical_content table.th_green,
.mc_box table.th_green,
table.th_green {
    width: 100%;
    border-collapse: collapse;
    margin: 0.9375rem 0;
    box-shadow: var(--box-shadow);
    /*border-radius: var(--border-radius);*/
    overflow: hidden;
}

.pharmaceutical_content table.th_green th,
.pharmaceutical_content table.th_green td,
.mc_box table.th_green th,
.mc_box table.th_green td,
table.th_green th,
table.th_green td {
    padding: 0.5rem 0.75rem;
    text-align: left;
    border: 1px solid #ccc;
}

.pharmaceutical_content table.th_green th,
.mc_box table.th_green th,
table.th_green th {
    background-color: #e2efda;
    color: #005b7f;
    font-weight: 400;
}

.pharmaceutical_content table.th_green tr td:first-child,
.pharmaceutical_content table.th_green tr th:first-child,
.mc_box table.th_green tr td:first-child,
.mc_box table.th_green tr th:first-child,
table.th_green tr td:first-child,
table.th_green tr th:first-child {
    width: 20%;
}

.pharmaceutical_content table.th_green tr td:not(:first-child),
.pharmaceutical_content table.th_green tr th:not(:first-child),
.mc_box table.th_green tr td:not(:first-child),
.mc_box table.th_green tr th:not(:first-child),
table.th_green tr td:not(:first-child),
table.th_green tr th:not(:first-child) {
    width: auto;
}

/* .pharmaceutical_content table.th_green tr:nth-child(even),
.mc_box table.th_green tr:nth-child(even),
table.th_green tr:nth-child(even) {
    background-color: #f5fbfd;
} */

/* .pharmaceutical_content table.th_green tr:hover,
.mc_box table.th_green tr:hover,
table.th_green tr:hover {
    background-color: #d1e8f0;
} */


/* テーブルスタイル - 薄い黄色 */
.pharmaceutical_content table.th_yellow,
.mc_box table.th_yellow,
table.th_yellow {
    width: 100%;
    border-collapse: collapse;
    margin: 0.9375rem 0;
    box-shadow: var(--box-shadow);
    /*border-radius: var(--border-radius);*/
    overflow: hidden;
}

.pharmaceutical_content table.th_yellow th,
.pharmaceutical_content table.th_yellow td,
.mc_box table.th_yellow th,
.mc_box table.th_yellow td,
table.th_yellow th,
table.th_yellow td {
    padding: 0.5rem 0.75rem;
    text-align: left;
    /*border: 1px solid #d1e8f0;*/
    border: none;
    border-top: 1px solid #ddd;
    border-bottom: 1px solid #ddd;
    border-right: 1px solid #ddd;
}

.pharmaceutical_content table.th_yellow th,
.mc_box table.th_yellow th,
table.th_yellow th {
    /*background-color: #ffffcc;*/
    background-color: #e0f4fa;
    color: #005b7f;
    font-weight: 400;
}

.pharmaceutical_content table.th_yellow tr td:first-child,
.pharmaceutical_content table.th_yellow tr th:first-child,
.mc_box table.th_yellow tr td:first-child,
.mc_box table.th_yellow tr th:first-child,
table.th_yellow tr td:first-child,
table.th_yellow tr th:first-child {
    width: 20%;
}

.pharmaceutical_content table.th_yellow tr td:not(:first-child),
.pharmaceutical_content table.th_yellowtr th:not(:first-child),
.mc_box table.th_yellow tr td:not(:first-child),
.mc_box table.th_yellow tr th:not(:first-child),
table.th_yellow tr td:not(:first-child),
table.th_yellow tr th:not(:first-child) {
    width: auto;
}


/* .pharmaceutical_content table.th_yellow tr:nth-child(even),
.mc_box table.th_yellow tr:nth-child(even),
table.th_yellow tr:nth-child(even) {
    background-color: #f5fbfd;
}

.pharmaceutical_content table.th_yellow tr:hover,
.mc_box table.th_yellow tr:hover,
table.th_yellow tr:hover {
    background-color: #d1e8f0;
} */


/* テーブルスタイル - 薄いピンク */
.pharmaceutical_content table.th_pink,
.mc_box table.th_pink,
table.th_pink {
    width: 100%;
    border-collapse: collapse;
    margin: 0.9375rem 0;
    box-shadow: var(--box-shadow);
    /*border-radius: var(--border-radius);*/
    overflow: hidden;
}

.pharmaceutical_content table.th_pink th,
.pharmaceutical_content table.th_pink td,
.mc_box table.th_pink th,
.mc_box table.th_pink td,
table.th_pink th,
table.th_pink td {
    padding: 0.5rem 0.75rem;
    text-align: left;
    border: 1px solid #d1e8f0;
}

.pharmaceutical_content table.th_pink th,
.mc_box table.th_pink th,
table.th_pink th {
    /*background-color: #ffccff;*/
    background-color: #e0f4fa;
    color: #005b7f;
    font-weight: 400;
}

.pharmaceutical_content table.th_pink tr td:first-child,
.pharmaceutical_content table.th_pink tr th:first-child,
.mc_box table.th_pink tr td:first-child,
.mc_box table.th_pink tr th:first-child,
table.th_pink tr td:first-child,
table.th_pink tr th:first-child {
    width: 20%;
}

.pharmaceutical_content table.th_pink tr td:not(:first-child),
.pharmaceutical_content table.th_pink tr th:not(:first-child),
.mc_box table.th_pink tr td:not(:first-child),
.mc_box table.th_pink tr th:not(:first-child),
table.th_pink tr td:not(:first-child),
table.th_pink tr th:not(:first-child) {
    width: auto;
}

/* .pharmaceutical_content table.th_pink tr:nth-child(even),
.mc_box table.th_pink tr:nth-child(even),
table.th_pink tr:nth-child(even) {
    background-color: #f5fbfd;
}

.pharmaceutical_content table.th_pink tr:hover,
.mc_box table.th_pink tr:hover,
table.th_pink tr:hover {
    background-color: #d1e8f0;
} */


/* ファイルリンク */
.file_link {
    display: inline-flex;
    align-items: center;
    color: var(--secondary-color);
    text-decoration: none;
    font-weight: 400;
    transition: all 0.3s;
    margin: 2px 0;
}

.file_link:hover {
    color: var(--primary-color);
}

/* ファイルタイプアイコン */
.file_icon {
    margin-right: 0.5rem;
    font-size: 1.1em;
}

.file_icon.pdf {
    color: #e74c3c;
}

.file_icon.doc {
    color: #2b579a;
}

.file_icon.xls {
    color: #217346;
}

.file_icon.ppt {
    color: #d24726;
}

.file_icon.txt {
    color: #5f6368;
}

.file_icon.zip {
    color: #f7b731;
}

.file_icon.link {
    color: #0078d7;
}

/* コンテンツボックス */
.mc_box {
    padding: 1.25rem;
    margin: 1.25rem 0;
}

.detail_box {
    border-bottom: 1px dashed #ddd;
    padding: 0.625rem 0;
}

.detail_box ul {
    padding-left: 1.25rem;
    margin-bottom: 0.9375rem;
}

.detail_box ul li {
    margin-bottom: 0.8rem;
    padding-left: 1.25rem;
    position: relative;
    line-height: 1.6;
}

.detail_box ul li a {
    color: #00a0c1;
    text-decoration: none;
    transition: color 0.3s;
    gap: 0.625rem;
}

.detail_box ul li a:hover {
    color: #005b7f;
    text-decoration: underline;
}

/* 表組み */
.researcher_table {
    width: 100%;
    border-collapse: collapse;
    margin: 0.9375rem 0;
}

.researcher_table th {
    background-color: #e6f7fa;
    border: 1px solid #ccc;
    padding: 0.5rem 0.75rem;
    text-align: left;
    font-weight: 500;
    width: 20%;
}

.researcher_table td {
    border: 1px solid #ccc;
    padding: 0.5rem 0.75rem;
}

/* PDFサムネイル表示 */
.pdf_thumbnail {
    margin: 1.25rem 0;
    text-align: center;
}

.thumbnail_link {
    display: inline-block;
    text-decoration: none;
    color: #333;
    transition: all 0.3s ease;
}

.pdf_thumbnail a{
    text-decoration: underline;
}

.thumbnail_img {
    box-sizing: border-box;
    padding: 0.5rem;
    max-width: 100%;
    height: auto;
    border: 1px solid #ddd;
    box-shadow: 0 2px 0.3125rem rgba(0, 0, 0, 0.1);
    transition: all 0.3s ease;
}

.thumbnail_link:hover .thumbnail_img {
    box-shadow: 0 0.25rem 0.5rem rgba(0, 0, 0, 0.2);
    transform: translateY(-2px);
}

.thumbnail_text {
    margin-top: 0.625rem;
    font-size: 0.9rem;
    color: #005b7f;
}

.thumbnail_link:hover .thumbnail_text {
    text-decoration: underline;
    color: #00a0c1;
}

/* 手続きページ用スタイル */
.content_area p {
    margin-bottom: 0;
}

.flow_dl dt {
    font-size: 1.2rem;
    font-weight: 700;
    color: #005b7f;
    margin-bottom: 0.9375rem;
    padding-bottom: 0.5rem;
    border-bottom: 2px solid #fac657;
}

.procedure_cont_box {
    margin-bottom: 2.5rem;
    margin-top: 2.5rem;
    padding-bottom: 1.875rem;
    border-bottom: 1px dashed #ddd;
}

.procedure_cont_box:last-child {
    border-bottom: none;
    padding-bottom: 0;
}

.procedure_dl dt {
    font-size: 1.2rem;
    font-weight: 700;
    color: #005b7f;
    margin-bottom: 0.9375rem;
    padding-bottom: 0.5rem;
    border-bottom: 2px solid #fac657;
}

.procedure_dl dd {
    margin-bottom: 1.25rem;
    line-height: 1.6;
}

.shiryou_list_karute {
    padding-left: 0.5rem;
    margin-bottom: 1.25rem;
}
.link_name {
    /*color: #005ba3;*/
}

.shorui_list_karute {
    margin-bottom: 1.25rem;
}

.shiryou_list,
.shorui_list {
    list-style: none;
    padding-left: 0;
    margin-bottom: 1.25rem;
}

.shiryou_list_karute li {
    margin-bottom: 0.9375rem;
    line-height: 1.5;
}

.shorui_list_karute li {
    margin-bottom: 0.9375rem;
    line-height: 1.5;
    padding-left: 1.2rem;
    position: relative;
}

.shorui_list_karute li::before {
    content: "";
    display: block;
    width: 0.625rem;
    height: 0.625rem;
    border-radius: 50%;
    background-color: #005b7f;
    position: absolute;
    top: 0.5rem;
    left: 0.2rem;
}

.shiryou_list li,
.shorui_list li {
    margin-bottom: 0.9375rem;
    line-height: 1.5;
}

.non_link_item {
    font-weight: 500;
    color: #333;
    display: inline-block;
    /*padding-left: 1.25rem;*/
    /* アイコンとマージンの幅に合わせる */
}

.lbl_file_size {
    font-size: 0.85rem;
    color: #666;
    margin-left: 0.3125rem;
}

.note_text {
    display: block;
    font-size: 0.9rem;
    color: #666;
    margin-top: 0.3125rem;
    padding-left: 1.25rem;
    line-height: 1.4;
}

.shien_list {
    list-style: none;
    padding-left: 0;
    margin-bottom: 1.25rem;
}

.shien_list li {
    margin-bottom: 0.8rem;
    line-height: 1.5;
    padding-left: 1.2rem;
    position: relative;
}

.shien_list li::before {
    content: "";
    display: block;
    width: 0.625rem;
    height: 0.625rem;
    border-radius: 50%;
    background-color: #005b7f;
    position: absolute;
    top: 0.5rem;
    left: 0.2rem;
}

.u_line {
    text-decoration: underline;
    font-weight: 500;
}

.procedure_hiyou {
    margin: 1.5625rem 0 0.9375rem;
    padding: 0.9375rem;
    background-color: #f9f9f9;
    border-left: 0.25rem solid #ffa500;
    font-size: 0.95rem;
    line-height: 1.6;
}

.case_list {
    margin: 1.25rem 0;
}

.case_dl {
    margin-bottom: 1.5625rem;
    padding: 0.9375rem;
    background-color: #f5fbfd;
    border-radius: 0.375rem;
}

.case_dl dt {
    font-size: 1.1rem;
    font-weight: 600;
    color: #005b7f;
    margin-bottom: 0.9375rem;
    padding-bottom: 0.5rem;
    border-bottom: 1px solid #ddd;
}

.case_dl dd {
    line-height: 1.5;
}

.download_btn_td{
    /*
    display: flex;
    justify-content: space-between;
    align-items: center;
    */
}

.link_name_dl{
    display: flex;
    align-items: flex-start;
}

.link_name_dl .link_name{
    flex: 1;
    padding-right: 1em;
}

.link_name_dl .link_download{
    width: 5em;
    
}


/* お問い合わせボックス */
.mc_box {
    padding: 0 1.25rem;
    margin: 1.25rem 0;
}

.fw_bold {
    font-weight: 700;
}



/* 準備中メッセージのスタイル */
.preparing {
    font-size: 1.1rem;
    color: #666;
    text-align: center;
    padding: 3.125rem 0;
    font-weight: 500;
}

/* 医師主導治験ページのスタイル */
ul.ishishudo_list {
    padding-left: 0;
    margin-bottom: 0;
}

ul.ishishudo_list li {
    margin-bottom: 0.8rem;
    padding-left: 1.25rem;
    position: relative;
    line-height: 1.6;
}

ul.ishishudo_list li::before {
    content: "";
    display: block;
    width: 0.625rem;
    height: 0.625rem;
    border-radius: 50%;
    background-color: #005b7f;
    position: absolute;
    top: 0.5rem;
    left: 0.2rem;
}

.citation {
    text-align: right;
    font-size: 0.9rem;
    color: #666;
    margin-top: 1rem;
    font-style: italic;
}

/* 支援依頼ページのスタイル */
.assistance_list {
    list-style-type: none;
    padding: 0;
    margin-bottom: 1.5rem;
}

.assistance_list li {
    margin-bottom: 1.2rem;
    padding-left: 0;
    line-height: 1.6;
}

.assistance_list .note_text {
    display: inline-block;
    margin-left: 0.5rem;
    font-size: 0.9rem;
    color: #666;
}

.assistance_img {
    position: relative;
    display: inline-block;
    margin-top: 1rem;
}

.assistance_img .assistance_link {
    display: block;
    position: absolute;
    background-color: rgba(255, 255, 255, 0);
    top: 15.3%;
    left: 26%;
    width: 11.6%;
    height: 1.4%;
    /*border-bottom: 1px solid #222;*/
}

.assistance_img .assistance_file {
    display: block;
    position: absolute;
    /*
    background-color: rgba(255, 255, 255, 0);
    top: 21.3%;
    left: 60%;
    */
    top: 15%;
    left: 26.1%;
    border-bottom: 1px solid #005b7f;
    text-decoration: none;
    font-size: 0.72rem;
    background: #fff79e;
    color: #0000ff;
}

.assistance_img .assistance_file:hover {
    border-bottom: 1px solid #005b7f;
    opacity: 1;
}

.assistance_img .assistance_file .file_icon {
    margin-right: 0.2rem;
}

/* 直接閲覧ページのスタイル */
.direct_viewing_flow {
    margin-bottom: 2rem;
}

.flow_title {
    font-size: 1.1rem;
    font-weight: 700;
    color: var(--secondary-color);
    margin: 1.5rem 0 0.8rem;
    padding-bottom: 0.3rem;
    border-bottom: 1px solid #e0e0e0;
}

.flow_title.first {
    margin: 0 0 0.8rem 0;
}

.contact_dl dt,
.request_dl dt {
    font-weight: 700;
    margin-bottom: 0.5rem;
    color: #333;
}

.contact_dl dd,
.request_dl dd {
    margin-bottom: 1.2rem;
}

.contact_table {
    width: 100%;
    border-collapse: collapse;
    margin-bottom: 1rem;
}

.contact_table th,
.contact_table td {
    padding: 0.8rem;
    border: 1px solid #ddd;
    line-height: 1.5;
}

.contact_table th {
    /*background-color: #f5f5f5;*/
    background-color: rgba(0, 160, 184, 0.08);
    width: 30%;
    text-align: left;
    font-weight: 600;
}

.contact_table_tantou {
    width: 100%;
    border-collapse: collapse;
    margin-bottom: 1rem;
}

.contact_table_tantou th,
.contact_table_tantou td {
    padding: 0.8rem;
    border: 1px solid #ddd;
    line-height: 1.5;
}

.contact_table_tantou th {
    background-color: #f5f5f5;
    width: 20%;
    text-align: left;
    font-weight: 600;
}

.detail_box .contact_table td ul {
    padding-left: 0;
    margin-bottom: 0;
}

.contact_table td ul li {
    padding-left: 1rem;
    position: relative;
}

.contact_table td ul li::before {
    content: "";
    display: block;
    width: 0.625rem;
    height: 0.625rem;
    border-radius: 50%;
    background-color: #005b7f;
    position: absolute;
    top: 0.5rem;
    left: 0.2rem;
}

.document_list {
    list-style-type: none;
    padding-left: 0;
    margin-bottom: 1.5rem;
}

.document_list li {
    margin-bottom: 0.8rem;
    line-height: 1.5;
}

.note_list {
    list-style-type: disc;
    padding-left: 1.5rem;
    margin-bottom: 1rem;
}

.note_list li {
    margin-bottom: 0.8rem;
    line-height: 1.5;
}

.request_dl dd ul li::before {
    content: "";
    display: block;
    width: 0.625rem;
    height: 0.625rem;
    border-radius: 50%;
    background-color: #005b7f;
    position: absolute;
    top: 0.5rem;
    left: 0.2rem;
}

.fw_bold {
    font-weight: 700;
}

.fc_red {
    color: #e74c3c;
}

.p_tantou {
    text-decoration: underline;
}

/*ライセンス*/


dl.dd_left_margin dd.license_kitei {
    margin-top: 0.5rem;
}

dl.dd_left_margin dd.license_kitei dl {
    display: flex;
    margin-bottom: 0.5rem;
}


dl.dd_left_margin dd.license_kitei dl dd {
    margin-left: 1rem;
}

table.num_list th,
table.num_list td {
    border: none;
    vertical-align: top;
    padding: 0 0 0.6em 0;
}

table.num_list th {
    width: 1.5em;
}

.license_teishutsusaki {
    text-align: center;
    font-size: 1.2em;
    margin: 1em 0 1em 0;
}

.license_teishutsusaki span {
    text-decoration: underline;
}

.content_subtitle {
    font-size: 1.25rem;
    font-weight: 500;
    color: var(--secondary-color);
    margin: 1.875rem 0 0.9375rem;
}

.link_btn_list ul {
    display: flex;
    justify-content: center;
    gap: 2rem;
}

.link_btn_list ul li a {
    box-sizing: border-box;
    display: inline-block;
    background-color: #f3933a;
    color: #fff;
    font-size: 0.9rem;
    padding: 0.9375rem 1.5625rem;
    border-radius: 3.125rem;
    text-decoration: none;
    font-weight: 500;
    transition: all 0.3s ease;
    box-shadow: 0 2px 5px rgba(0, 0, 0, 0.1);
}

.link_btn_list ul li a:hover {
    background-color: #e67e1b;
    box-shadow: 0 4px 8px rgba(0, 0, 0, 0.15);
    transform: translateY(-2px);
}

.menu_btn_wrap ul {
    margin: 1rem 1rem 0 1rem;
    display: flex;
    justify-content: flex-start;
    flex-wrap: wrap;
    gap: 0.3rem 1rem;
}

.menu_btn_wrap ul li {
    font-size: 0.9rem;
    padding-left: 1rem;
    position: relative;
}

.menu_btn_wrap ul li::before {
    content: "";
    display: block;
    width: 0.5rem;
    height: 0.5rem;
    background-color: #f3933a;
    border-radius: 50%;
    position: absolute;
    left: 0;
    top: 0.5rem;
}

/* レスポンシブ対応 */
@media screen and (max-width: 767px) {

    .researcher_table th,
    .researcher_table td {
        display: block;
        width: 100%;
    }

    .researcher_table th {
        border-bottom: none;
    }

    .mc_box {
        padding: 0.9375rem;
    }

    .detail_box ul {
        padding-left: 0.9375rem;
    }
}

@media screen and (min-width:1px) and (max-width:479px) {
    .mc_box {
        padding: 0;
    }

    .detail_box ul li a {
        gap: 0.225rem;
    }

    .link_btn_list ul {
        margin-top: 2.5rem;
        flex-direction: column;
        justify-content: center;
        align-items: center;
        gap: 1rem;
    }

    .link_btn_list ul li {
        width: 90%;
    }

    .link_btn_list ul li a {
        display: block;
        padding: 0.9375rem 1rem;
    }

    .mc_box.mc_contact {
        padding: 0;
        margin: 2.5rem 0 1.25rem 0 !important;
    }

    .assistance_img .assistance_file {
        display: block;
        position: absolute;
        top: 14.8%;
        left: 26.1%;
        border-bottom: 1px solid #005b7f;
        text-decoration: none;
        font-size: 0.34rem;
        background: #fff;
    }

    ul.ishishudo_list {
        padding-left: 0;
    }

    .file_link {
        display: inline;
    }

    .contact_table th {
        text-align: center;
    }

    .contact_table th,
    .contact_table td {
        padding: 0.8rem 0.5rem;
    }

    .pharmaceutical_content table.th_yellow tr td:first-child,
    .pharmaceutical_content table.th_yellow tr th:first-child,
    .mc_box table.th_yellow tr td:first-child,
    .mc_box table.th_yellow tr th:first-child,
    table.th_yellow tr td:first-child,
    table.th_yellow tr th:first-child {
        width: 30%;
    }

    .pharmaceutical_content table.th_pink tr td:first-child,
    .pharmaceutical_content table.th_pink tr th:first-child,
    .mc_box table.th_pink tr td:first-child,
    .mc_box table.th_pink tr th:first-child,
    table.th_pink tr td:first-child,
    table.th_pink tr th:first-child {
        width: 30%;
    }

}