Tomita Y, Yuno A, Tsukamoto H, Senju S, Kuroda Y, Hirayama M, Imamura Y, Yatsuda J, Sayem M, Irie A, Hamada A, Jono H, Yoshida K, Tsunoda T, Daigo Y, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, and Nishimura Y.
LY6K-specific CD4+ T-cell immunity in patients with malignant tumor: Identification of LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes.
OncoImmunology, 2014, in press.

Taguchi K, Kouroki, M, Ohmura T, Jono H, Endo F, and Saito H.
Carbamazepine-imatinib interaction in a child with chronic myeloid leukemia.
Pediatr Int., 2014, in press.

Yanagisawa A, Ueda M, Sueyoshi T, Okada T, Fujimoto T, Ogi Y, Kitagawa K, Tasaki M, Misumi Y, Oshima T, Jono H, Obayashi K, Hirakawa K, Uchida H, Westermark P, Ando Y, Mizuta H.
Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis.
Mod Pathol, 2014, in press.

Guo J, Shinriki S, Su Y, Nakamura T, Hayashi M, Tsuda Y, Murakami Y, Tasaki M, Hide T, Takezaki T, Kuratsu J, Yamashita S, Ueda M, Li JD, Ando Y, Jono H.
Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy.
Oncotarget, 2014 Aug 30;5(15):6353-64.

Anno T, Higashi T, Hayashi Y, Motoyama K, Jono H, Ando Y, Arima H.
Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a siRNA carrier for the treatment of familial amyloidotic polyneuropathy.
J Drug Target, 2014, in press.

Oshima T, Kawahara S, Ueda M, Kawakami Y, Tanaka R, Okazaki T, Misumi Y, Obayashi K, Yamashita T, Ohya Y, Ihse E, Shinriki S, Tasaki M, Jono H, Asonuma K, Inomata Y, Westermark P, Ando Y.
Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation.
J Neurol Neurosurg Psychiatry, 2014 Jul;85(7):740-6.

Saito H, Yoshimura M, Saigo C, Komori M, Nomura Y, Yamamoto Y, Sagata M, Wakida A, Chuman E, Nishi K, Jono H.
Hepatic Sulfotransferase as a Nephropreventing Target by Suppression of the Uremic Toxin Indoxyl Sulfate Accumulation in Ischemic Acute Kidney Injury.
Toxicol Sci, 2014, in press.

Yamakawa Y, Hamada A, Uchida T, Sato D, Yuki M, Hayashi M, Kawaguchi T, Saito H.
Distinct Interaction of Nilotinib and Imatinib with P-Glycoprotein in Intracellular Accumulation and Cytotoxicity in CML Cell Line K562 Cells.
Biol Pharm Bull, 2014;37(8):1330-5.

Isono K, Jono H, Ohya Y, Shiraki N, Yamazoe T, Sugasaki A, Era T, Fusaki N, Tasaki M, Ueda M, Shinriki S, Inomata Y, Kume S, Ando Y.
Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells.
Stem Cell Res, 2014 Mar;12(2):574-83.

Hayashi M, Jono H, Shinriki S, Nakamura T, Guo J, Sueta A, Tomiguchi M, Fujiwara S, Yamamoto-Ibusuki M, Murakami K, Yamashita S, Yamamoto Y, Li JD, Iwase H, Ando Y.
Clinical significance of CYLD downregulation in breast cancer.
Breast Cancer Res Treat, 2014 Feb;143(3):447-57.

Shinriki S, Jono H, Ueda M, Obayashi K, Nakamura T, Ota K, Ota T, Sueyoshi T, Guo J, Hayashi M, Hiraki A, Nakayama H, Yamashita S, Shinohara M, Ando Y.
Stromal expression of neutrophil gelatinase-associated lipocalin correlates with poor differentiation and adverse prognosis in oral squamous cell carcinoma.
Histopathology, 2014 Feb;64(3):356-64.

Tomita Y, Yuno A, Tsukamoto H, Senju S, Yoshimura S, Osawa R, Kuroda Y, Hirayama M, Irie A, Hamada A, Jono H, Yoshida K, Tsunoda T, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, Nishimura Y.
Identification of CDCA1-derived long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients.
Int J Cancer, 2014 Jan;134(2):352-66.

Saigo C, Nomura Y, Yamamoto Y, Sagata M, Matsunaga R, Jono H, Nishi K, Saito H.
Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters.
Drug Des Devel Ther, 2014 Aug 13;8:1073-82.

Taguchi K, Jono H, Kugimiya-Taguchi T, Nagao S, Su Y, Yamasaki K, Mizuguchi M, Maruyama T, Ando Y, Otagiri M.
Effect of albumin on transthyretin and amyloidogenic transthyretin Val30Met disposition and tissue deposition in familial amyloidotic polyneuropathy.
Life Sci, 2013 Dec 18;93(25-26):1017-22.

Tasaki M, Ueda M, Obayashi K, Koike H, Kitagawa K, Ogi Y, Jono H, Su Y, Suenaga G, Oshima T, Misumi Y, Yoshida M, Yamashita T, Sobue G, Ando Y.
Effect of age and sex differences on wild-type transthyretin amyloid formation in familial amyloidotic polyneuropathy: a proteomic approach.
Int J Cardiol, 2013 Dec 5;170(1):69-74.

Taguchi K, Ohmura T, Ohya Y, Horio M, Furukawa K, Jono H, Inomata Y, Saito H.
False Tacrolimus Concentrations Measured By Antibody-Conjugated Magnetic Immunoassay in Liver Transplant Patient: 2 Case Reports and Literature Review.
Exp Clin Transplant, 2013, in press.

Hashiguchi Y, Hamada A, Shinohara T, Tsuchiya K, Jono H, Saito H.
Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents.
Biochem Biophys Res Commun, 2013 Sep 20;439(2):221-7.

Komatsu K, Lee JY, Miyata M, Hyang Lim J, Jono H, Koga T, Xu H, Yan C, Kai H, Li JD.
Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD.
Nature Commun, 2013;4:1684

Tomita Y, Akira Y, Tsukamoto H, Senju S, Kuroda Y, Hirayama M, Irie A, Kawahara K, Yatsuda J, Hamada A, Jono H, Yoshida K, Tsunoda T, Kohrogi H, Yoshitake Y, Nakamura Y, Shinohara M, Nishimura Y.
Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor.
Clin Cancer Res, 2013 Aug 15;19(16):4508-20.

Ihse E, Rapezzi C, Merlini G, Benson MD, Ando Y, Suhr OB, Ikeda SI, Lavatelli F, Obici L, Quarta CC, Leone O, Jono H, Ueda M, Lorenzini M, Liepnieks J, Ohshima T, Tasaki M, Yamashita T, Westermark P.
Amyloid fibrils containing fragmented ATTR may be the standard fibril composition in ATTR amyloidosis.
Amyloid, 2013 Sep;20(3):142-50.

Nonoguchi H, Izumi Y, Nakayama Y, Matsuzaki T, Yasuoka Y, Inoue T, Inoue H, Mouri T, Kawahara K, Saito H and Tomita K.
Effects of atrial natriuretic peptide on bicarbonate transport in long- and short-looped medullary thick ascending limbs of rats.
Am J Physiol-Renal Physiol, 2013 Dec 23;8(12):e83146

Obayashi K, Tasaki M, Jono H, Ueda M, Shinriki S, Misumi Y, Yamashita T, Oshima T, Nakamura T, Ikemizu S, Anan I, Suhr O, Ando Y
Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine.
Clin Chim Acta, 2013 Apr 18;419:127-31.

Kinoshita H, Okabe H, Beppu T, Chikamoto A, Hayashi H, Imai K, Mima K, Nakagawa S, Yokoyama N, Ishiko T, Shinriki S, Jono H, Ando Y, Baba H.
CYLD downregulation is correlated with tumor development in patients with hepatocellular carcinoma.
Biochem Pharmacol, 2013 Mar;1(2):309-314.

Saito H.
Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases
Biochem Pharmacol, 2013 Apr;85(7):865-72.

Hayashi Y, Higashi T, Motoyama K, Mori Y, Jono H, Ando Y, Arima H.
Design and evaluation of polyamidoamine dendrimer conjugate with PEG, α-cyclodextrin and lactose as a novel hepatocyte-selective gene carrier in vitro and in vivo.
J. Drug Target, 2013 May;21(5):487-96.

Taguchi K, Miyakawa T, Ohmura T, Horio M, Anraku Y, Okada T, Mizuta H, Saito H, Kawaguchi T.
A reduced linezolid dosage maintains favorable efficacy with minimal hematologic toxicity in a methicillin-resistant Staphylococcus aureus-infected patient with renal insufficiency.
Scand J Infect Dis, 2013 Jan;45(1):77-80

Obayashi K, Ueda M, Oshima T, Kawahara S, Misumi Y, Yamashita T, Jono H, Yazaki M, Kametani F, Ikeda S, Ohya Y, Asonuma K, Inomata Y, Ando Y.
Pathological changes long after liver transplantation in a familial amyloidotic polyneuropathy patient.
BMJ Case Rep, 2012 Aug 18;

Jono H, Anno T, Motoyama K, Misumi Y, Tasaki M, Oshima T, Mori Y, Mizuguchi M, Ueda M, Shinriki S, Shono M, Obayashi K, Arima H, Ando Y.
Potential use of glucuronylglucosyl-β-cyclodextrin as a novel therapeutic tool for familial amyloidotic polyneuropathy.
Amyloid, 2012, Jun; Suppl 1: 50-2.

Lee J, Komatsu K, Lee BC, Lim JH, Jono H, Xu H, Kai H, Zhang ZJ, Yan C, Li JD.
Phosphodiesterase 4B Mediates Extracellular Signal-regulated Kinase-dependent Up-regulation of Mucin MUC5AC Protein by Streptococcus pneumoniae by Inhibiting cAMP-protein Kinase A-dependent MKP-1 Phosphatase Pathway.
J Biol Chem, 2012 Jun; 287(27):22799-811.

Hayashi Y, Mori Y, Yamashita S, Motoyama K, Higashi T, Jono H, Ando Y, Arima H.
Potential use of lactosylated dendrimer (G3)/α-cyclodextrin conjugates as hepatocyte-specific siRNA carriers for the treatment of familial amyloidotic polyneuropathy.
Mol Pharm, 2012 Jun; 9(6):1645-53.

Su Y, Jono H, Torikai M, Hosoi A, Soejima K, Guo J, Tasaki M, Misumi Y, Ueda M, Shinriki S, Shono M, Obayashi K, Nakashima T, Sugawara K, Ando Y.
Antibody therapy for familial amyloidotic polyneuropathy.
Amyloid, 2012 Jun; Suppl 1: 45-6.

Ota T, Jono H, Ota K, Shinriki S, Ueda M, Sueyoshi T, Nakatani K, Hiraish

i Y, Wada T, Fujita S, Obayashi K, Shinohara M, Ando Y.
Downregulation of midkine induces cisplatin resistance in human oral squamous cell carcinoma.
Oncol Rep, 2012 May; 27(5): 1674-80.

Iwata K, Aizawa K, Kamitsu S, Jingami S, Fukunaga E, Yoshida M, Yoshimura M, Hamada A, Saito H.
Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events.
Clin Exp Nephrol, 2012 Dec;16(6):843-51.

Jono H, Lim JH, Xu H, Li JD.
PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1.
PLoS ONE, 7: e31049. 2012.

Lim JH*, Jono H*, Komatsu K, Dr. Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, Park SH, Kim YI, Choi YD, Shen H, Heo KS, Xu H, Bourne P, Koga T, Xu H, Yan C, Wang B, Chen LF, Feng XH, Li JD.
CYLD Negatively Regulates Transforming Growth Factor-Signaling via Deubiquitinating Akt.
Nature Commun, 2012 Apr 10;3:771. (*These authors contributed equally to this work)

Hamada A, Sasaki J, Saeki S, Iwamoto N, Inaba M, Ushijima S, Urata M, Kishi H, Fujii S, Semba H, Kashiwabara K, Tsubata Y, Kai Y,Isobe T, Kohrogi H, Saito H.
Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small-cell lung cancer.
Pharmacogenomics, 2012 Apr 13 (5):615-24.

Kugimiya T*, Jono H*, Saito S*, Maruyama M, Kadowaki D, Misumi Y, Hoshii Y, Tasaki T, Su Y, Ueda M, Obayashi K, Shono M, Otagiri M, Ando Y. Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy.
Lab Invest, 91: 1219-28, 2011 (*These authors contributed equally to this work)

Nambu T, Hamada A, Nakashima R, Yuki M, Kawaguchi T, Mitsuya H, Saito H.
Association of SLCO1B3 polymorphism with intracellular accumulation of imatinib in leukocytes in patients with chronic myeloid leukemia.
Biol Pharm Bull, 2011;34(1):114-9.

Jono H, Anno T, Motoyama K, Misumi Y, Tasaki M, Ohshima T, Mori Y, Mizuguchi M, Ueda M, Shono M, Obayashi K, Arima H, Ando Y.
Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis.
Biochem J, 437: 35-42, 2011

Masuda T, Hattori N, Hamada A, Iwamoto H, Ohshimo S, Kanehara M, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Kohno N.
Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy.
Cancer Chemother Pharmacol, 2011;67(6):1465-9.

Kato T, Hamada A, Mori S, Saito H.
Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese patients with rheumatoid arthritis.
Drug Metab Pharmacokinet, 2011 Nov 22

Iwata K, Aizawa K, Sakai S, Jingami S, Fukunaga E, Yoshida M, Hamada A, Saito H.
The relationship between treatment time of gemcitabine and development of hematologic toxicity in cancer patients.
Biol Pharm Bull, 2011;34(11):1765-8.

Kusumoto M, Kamobayashi H, Sato D, Komori M, Yoshimura M, Hamada A, Kohda Y, Tomita K, Saito H.
Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats.
Clin Exp Nephrol, 2011 Dec;15(6):820-30.

Yuki M, Yamakawa Y, Uchida T, Nambu T, Kawaguchi T, Hamada A, Saito H.
High-performance liquid chromatographic assay for the determination of nilotinib in human plasma.
Biol Pharm Bull, 2011;34(7):1126-8.

Yamakawa Y, Hamada A, Shuto T, Yuki M, Uchida T, Kai H, Kawaguchi T, Saito H.
Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia.
Clin Pharmacol Ther, 2011 Jul;90(1):157-63

Yamakawa Y, Hamada A, Nakashima R, Yuki M, Hirayama C, Kawaguchi T, Saito H.
Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia.
Ther Drug Monit, 2011;33(2):244-50.